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qu’est-ce que la testostérone ?
a quoi sert la testotérone chez les hommes ?
la place des hormones masculines dans la sexualité
que se passe-t-il en cas de baisse de cette hormone ?
les liens entre prise de testostérone et diabète
cette vidéo est disponible dans les programmes suivants
ce cours a pour objet d’apprendre à représenter sous forme d’un schéma la. boucle de régulation dans le cas de la testostéronémie
tout commence avec un organe, qu’il faut écrire en majuscule, l’hypothalamus
l’hypothalamus fait partie du cerveau et produit une neurohormone, la gnrh
dans la représentation schématique, on peut encadrer l’organe, et dessiner par une flèche la sécrétion de la gnrh, une hormone permettant de libérer les gonadotrophines
cette gnrh agit positivement, stimule les cellules adénohypophysaires
on peut le représenter par une flèche affublée d’un plus
on peut écrire en majuscules adénohypophyse, et l’encadrer
il s’agit d’un ensemble de cellules à la surface desquelles il y a des récepteurs complémentaires à la gnrh
les cellules adénohypophysaires sont stimulées et produisent de la lh et de la fsh
là encore, on représente la production par une flèche, et on peut se contenter de représenter la lh (on n’utilisera pas la fsh dans cette boucle de régulation)
la lh stimule les cellules de leydig dans les testicules
le testicule est l’organe, on l’écrit donc en majuscule et encadré
ces cellules de leydig produisent alors en réponse de la testostérone
on le représente une nouvelle fois avec une flèche
elle exerce une rétroaction négative sur l’hypothalamus et l’adénohypophyse qu’il faut donc représenter avec un moins
imaginons un paramètre environnemental qui induit une forte augmentation (phase 1) de la gnrh, ce que l’on peut indiquer par une flèche allant vers le haut
cette neurohormone fortement concentrée stimule énormément les cellules adénohypophysaires
elles produisent en réponse une augmentation de la sécrétion de la lh, ce que l’on peut symboliser de nouveau par une flèche vers le haut
cette lh fortement concentrée stimule fortement les cellules de leydig, qui alors vont produire beaucoup de testostérone
le taux de testostérone s’élève, ce que l’on peut symboliser par une flèche vers le haut
si ce taux est élevé, la rétroaction sur l’hypophyse sera très forte
conséquence, dans une phase 2, l’hypothalamus est fortement inhibé donc son

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that would later be used in nintendo’s ds and 3ds handheld video game systems
in 2004, nintendo released the nintendo ds, its fourth major handheld system
the ds is a dual screened handheld featuring touch screen capabilities, which respond to either a stylus or the touch of a finger
former nintendo president and now chairman hiroshi yamauchi was translated by gamescience as explaining, “if we can increase the scope of the industry, we can re-energise the global market and lift japan out of depression – that is nintendo’s mission
” regarding lukewarm gamecube sales which had yielded the company’s first reported operating loss in over 100 years, yamauchi continued: “the ds represents a critical moment for nintendo’s success over the next two years
if it succeeds, we rise to the heavens, if it fails, we sink into hell
“[34][35][36] thanks to games such as nintendogs and mario kart ds, the ds became a success
in 2005, nintendo released the game boy micro in north america, a redesign of the game boy advance
the last system in the game boy line, it was also the smallest game boy, and the least successful
in the middle of 2005, nintendo opened the nintendo world store in new york city, which would sell nintendo games, present a museum of nintendo history, and host public parties such as for product launches
the store was renovated and renamed as nintendo new york in 2016
in the first half of 2006, nintendo released the nintendo ds lite, a version of the original nintendo ds with lighter weight, brighter screen, and better battery life
in addition to this streamlined design, its prolific subset of casual games appealed to the masses, such as the brain age series
meanwhile, new super mario bros
provided a substantial addition to the mario series when it was launched to the top of sales charts
the successful direction of the nintendo ds had a big influence on nintendo’s next home console (including the common nintendo wi-fi connection),[37] which had been codenamed “revolution” and was now renamed to “wii”
[citation needed ] in august 2006, nintendo published es, a now-dormant, open source research operating system project designed around web application integration but for no specific purpose
in the latter half of 2006, nintendo released the wii as the backward-compatible successor to the gamecube
based upon intricate wii remote motion controls and a balance board, the wii inspired several new game franchises, some targeted at entirely new market segments of casual and fitness gaming
selling more than 100 million worldwide, the wii was the best selling console of the seventh generation, regaining market share lost during the tenures of the nintendo 64 and gamecube
on 1 may 2007, nintendo acquired an 80% stake on video game development company monolith soft, previously owned by bandai namco
monolith soft is best known for developing role-playing games such as the xenosaga and baten kaitos series
during the holiday season of 2008, nintendo followed up the success of the ds with the release of the nintendo dsi in japan
the system features a more powerful cpu and more ram, two cameras, one facing towards the player and one facing outwards, and had an online distribution store called dsiware
the dsi was later released worldwide during 2009
in the latter half of 2009, nintendo released the nintendo dsi xl in japan, a larger version of the dsi
this updated system was later released worldwide in 2010
in 2011, nintendo released the nintendo 3ds, based upon a glasses-free stereoscopic 3d display
in february 2012, nintendo acquired mobiclip, a france-based research and development company specialised in highly optimised software technologies such as video compression
the company’s name was later changed to nintendo european research & development
[41] during the fourth quarter of 2012, nintendo released the wii u
it sold slower than expected,[42] despite being the first eighth generation console
by september 2013, however, sales had rebounded
[clarification needed ] intending to broaden the 3ds market, nintendo released 2013’s cost-reduced nintendo 2ds
the 2ds is compatible with but lacks the 3ds’s more expensive but cosmetic autostereoscopic 3d feature
nintendo also released the wii mini, a cheaper and non-networked redesign of the wii
on 25 september 2013, nintendo announced it had purchased a 28% stake in a panasonic spin-off company called pux corporation
the company specialises in face and voice recognition technology, with which nintendo intends to improve the usability of future game systems
nintendo has also worked with this company in the past to create character recognition software for a nintendo ds touchscreen
[43] after announcing a 30% dive in profits for the april to december 2013 period, president satoru iwata announced he would take a 50% pay-cut, with other executives seeing reductions by 20%–30%
in january 2015, nintendo announced its exit from the brazilian market after four years of distributing products in the country
nintendo cited high import duties and lack of local manufacturing operation as reasons for leaving
nintendo continues its partnership with juegos de video latinoamérica to distribute products to the rest of latin america
on 11 july 2015, iwata died from a bile duct tumor at the age of 55
following his death, representative directors genyo takeda and shigeru miyamoto jointly led the company on an interim basis until the appointment of tatsumi kimishima as iwata’s successor on 16 september 2015
[46] in addition to kimishima’s appointment, the company’s management organisation was also restructured—miyamoto was named “creative fellow” and takeda was named “technology fellow”
on 17 march 2015, nintendo announced a partnership with japanese mobile developer dena to produce games for smart devices
[48][49] the first of these, miitomo, was released in march 2016
on the same day, nintendo announced a new “dedicated games platform with a brand new concept” with the codename “nx” that would be further revealed in 2016
[49][51] reggie fils-aimé, president of nintendo of america, referred to nx as “our next home console” in a june 2015 interview with the wall street journal
[52] in a later article from october 2015, the wall street journal relayed speculation from unnamed inside sources that the nx was intended to feature “industry leading” hardware specifications and be usable as both a home and portable console
it was also reported that nintendo had begun distributing software development kits (sdks) for it to third-party developers, with the unnamed source further speculating that these moves suggested that the company was on track to introduce it as early as 2016
[53] at an investor’s meeting on 27 april 2016, nintendo announced that the nx would be released worldwide in march 2017
[54] in an interview with asahi shimbun in may 2016, kimishima stated that the nx was a new concept that would not succeed the 3ds or wii u product lines
[55] at a shareholders’ meeting following e3 2016, shigeru miyamoto stated that the company chose not to present the nx during the conference due to concerns that competitors could copy from it if they revealed it too soon
[56] the same day, kimishima also revealed during a q&a session with investors that they were also researching virtual reality
in may 2015, universal parks & resorts announced that it was partnering with nintendo to create attractions at universal theme parks based upon nintendo properties
[58] in may 2016, nintendo also expressed a desire to enter the animated film market
[59] in november 2016, it was stated that the area to be created at universal theme parks is known as super nintendo world, which will be completed by 2020 at universal studios japan in time of the 2020 tokyo olympics, whereas universal orlando resort and universal studios hollywood will get the themed area in an unspecified date after the japanese version
in july 2016, the company announced it was bringing back the nes in the form of the nes classic edition (called nintendo classic mini in europe)
the plug-and-play console will support hdmi, two-player modes, and have a controller similar to the original nes controller
the controller would be able to connect to a wii remote for use with wii and wii u virtual console games
the nes classic edition came with 30 games pre-installed, including final fantasy, kid icarus, the legend of zelda, zelda ii: the adventure of link, and dr
it was released in november 2016
additional controllers were also available
the july 2016 release of the pokémon go mobile app by niantic caused shares in nintendo to double, due to investor misunderstanding that the software was the property of nintendo
later that month, nintendo released a statement clarifying its relation with niantic, nintendo stated it owned 32% of pokémon intellectual property owner the pokémon company, and though it would receive some licensing and other revenues from the game it expected the impact on nintendo’s total income to be limited
as a result of the statement nintendo’s share price fell substantially, losing 17% in one day of trading
[62][63] after a reduction in shareprice from the pokémon go peak, the company was still valued at over 100 times its net income, a price–earnings ratio greatly exceeding the average on the nikkei 225
[64] analysts speaking to bloomberg l
and the financial times both commented on the potential future value of nintendo’s ip if transferred to the mobile phone game business
in august 2016, nintendo of america sold 90% of its controlling stake (55%) in the seattle mariners to a group of investors led by mobile phone businessman john stanton for $640 million
after the announcement of the mobile game super mario run in september 2016, nintendo’s stock soared to just under its recent high point after the release and success of pokémon go earlier in the year, something noted by journalists as even more significant than pokémon go, as super mario run was developed in-house by nintendo, which was not the case with pokémon go
[68] in a december 2016 interview prior to the release of super mario run, miyamoto explained that the company believed that with some of their game franchises, “the longer you continue to make a series, the more complex the gameplay becomes, and the harder it becomes for new players to be able to get into the series”, and that the company sees mobile games with simplified controls, such as

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