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explores the practical consequences of this assay in the management of prostate cancer
mots clés :  cancer de prostate, pronostic, testostérone
keywords :  prostate cancer, prognosis, testosterone
bienvenuesur em-consulte, la référence des professionnels de santé
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what should you wait of. a testosterone serum determination in a patient with prostate cancer?
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information destinées aux médecins généralistes, urologues, radiothérapeutes, oncologues, pharmaciens d’officine et hospitaliers, infirmiers
dans ce cadre, les conditions de prescription et de délivrance d’eligard® ont été modifiées afin que la poursuite du traitement soit subordonnée à la réalisation d’un dosage de la testostéronémie (t) tous les 3 mois
ces mesures s’ajoutent à celles déjà mises en place, notamment l’amélioration du dispositif d’administration, la mise à disposition des professionnels de santé de matériels éducationnels (poster, application smartphone, site internet* et vidéo) décrivant les étapes de préparation, reconstitution et administration d’eligard®
eligard®, poudre et solvant pour solution injectable (acétate de leuproréline) – réévaluation des conditions de prescription et de délivrance : réalisation d’un dosage de la testostéronémie – lettre aux professonnels de santé
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plusieurs erreurs médicamenteuses liées à des modalités d’administration inappropriées, notamment lors de la préparation, de la reconstitution et de. l’administration d’eligard (acétate de leuproréline), indiqué dans le traitement du cancer de la prostate, ont été signalées
elles peuvent entraîner un manque d’efficacité clinique
dans une lettre aux professionnels de santé, l’ansm a annoncé des modifications dans les conditions de prescription et de délivrance d’eligard
ainsi, la poursuite du traitement est désormais subordonnée tous les 3 mois à la réalisation d’un dosage de la testostéronémie
en pratique,

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for its era
the controller of the snes had also improved over that of the nes, as it now had rounded edges and four new buttons, a standard which is evident on many modern controllers today
nintendo had also begun development on a cd-rom attachment for the snes/super famicom
their first partner in this project was sony, whom nintendo had worked with before to provide the snes with its spc sound chip
development on the nintendo playstation cd-rom add-on and snes/sfc standalone hybrid console began
however, at the last minute nintendo decided to pull out of the partnership and instead go with philips, and while no cd-rom add-on was produced, several nintendo properties (namely the legend of zelda) appeared on the philips cd-i media console
upon learning this, sony decided to continue developing the technology they had into the playstation
the exact reason nintendo left its partnership with sony has been the subject of speculation over the years, but the most common theory is that sony either wanted too much of the profits for the machine or the rights to the cd-rom attachment itself
in japan, the super famicom easily took control of the gaming market
in the us, due to a late start and an aggressive marketing campaign by sega (headed by the sega company’s new mascot, sonic the hedgehog, their answer to nintendo’s super mario), nintendo saw its market share take a precipitous plunge from 90-95% with the nes to a low of approximately 35% against the sega genesis
over the course of several years, the snes in north america eventually overtook the genesis, thanks to franchise titles such as super mario world, the legend of zelda: a link to the past, street fighter ii, and the final fantasy series
total worldwide sales of the snes reached 49
10 million units,[20] eclipsing the estimated 40 million unit sales of the genesis
as the snes battled the sega genesis, nintendo was running into problems on another front caused by their own aggressive marketing behavior
in 1991, nintendo agreed to a settlement regarding price-fixing allegations brought by the federal trade commission and attorneys general in new york and maryland
nintendo had been accused of threatening to cut off shipments of the nes to retailers who discounted the price of the system
the estimated cost of the settlement was just under $30 million
in 1992, gunpei yokoi and the rest of r&d 1 began planning on a new virtual reality console to be called the virtual boy
hiroshi yamauchi also bought majority shares of the seattle mariners in 1992
[27] by may 1993, nintendo had reportedly become one of the top ten leading companies in the world
in 1993, nintendo announced plans to develop a new 64-bit console codenamed project reality that would be capable of rendering fully 3d environments and characters
in 1994, nintendo also claimed that project reality would be renamed ultra 64 in the us
the ultra 64 moniker was unveiled in arcades on the nintendo branded fighting game killer instinct and the racing game cruisin’ usa
killer instinct was later released on the snes
soon after, nintendo realized they had mistakenly chosen a name for their new console that the konami corporation owned the rights to
specifically, only konami would have the rights to release games for the new system called ultra football, ultra tennis, etc
therefore, in 1995 nintendo changed the final name of the system to the nintendo 64, and announced that it would be released in 1996
they later showed previews of the system and several games, including super mario 64, to the media and public
1995 is also the year that nintendo purchased part of rare
in 1994, after many years of nintendo’s products being distributed in australia by mattel since the nes in 1985, nintendo opened its australian headquarters and its first managing directors were graham kerry, who moved along from mattel australia as managing director and susumu tanaka of nintendo uk ltd
in 1995, nintendo released the virtual boy in japan
the console sold poorly, but nintendo still said they had hope for it and continued to release several other games and attempted a release in the us, which was another disaster
also in 1995, nintendo found themselves in a competitive situation
competitor sega introduced their 32-bit saturn, while newcomer sony introduced the 32-bit playstation
sony’s fierce marketing campaigns ensued, and it started to cut into nintendo and sega’s market share
on june 23, 1996, the nintendo 64 (n64) was released in japan, selling over 500,000 units on the first day of its release
[17] on september 29, 1996, nintendo released the nintendo 64 in north america, selling out the initial shipment of 350,000
[17] many feel that the advertising onslaught by sony at this time did not truly begin to take effect until many of the consumers who held out for the n64 became frustrated at the lack of software following the first few months after the system’s release
what also greatly contributed to the extremely competitive climate that nintendo was entrenched in was the fact that many third-party companies immediately began developing and releasing many of their leading games for nintendo’s competing consoles
many of those third party companies cited cheaper development and manufacturing costs for the cd format, versus the cartridge format
on december 1, 1999, nintendo released an add-on to the nintendo 64 in japan, titled the nintendo 64dd, although it was never released elsewhere
nintendo followed with the release of the game boy pocket, a smaller version of the original game boy, designed by gunpei yokoi as a parting gift
a week after the release of the game boy pocket, gunpei resigned from his position at nintendo
gunpei helped in the creation of a competitor system named the wonderswan, using the skills he gained in the creation of the game boy
in 1996, pocket monsters (known internationally as “pokémon”) was released in japan to a huge following
the pokémon franchise, created by satoshi tajiri, was proving so popular in america, europe, and japan, that for a brief time, nintendo took back their place as the supreme power in the games industry
in 1997, game boy and metroid creator gunpei yokoi died in a car accident at the age of 56
on october 13, 1998, the game boy color was released in japan, with releases in north america and europe a month later
nintendo released the game boy advance in japan on march 21, 2001, followed by the north american launch on june 11 and the european launch on june 22
nintendo released the gamecube home video game console on september 14, 2001, in japan
it was released in north america on november 18, 2001, europe on may 3, 2002, and australia on may 17, 2002
in january 2002, minoru arakawa resigned as president of nintendo of america, and nintendo named tatsumi kimishima as his successor
in may 2002, hiroshi yamauchi stepped down as the president of nintendo and named satoru iwata his successor
during the same year, nintendo and chinese-american scientist dr wei yen co-founded ique to manufacture and distribute official nintendo consoles and games for the mainland chinese market under the ique brand
[31] nintendo’s aggressive business tactics in europe would catch up to them
the european commission determined that nintendo had engaged in anticompetitive price-fixing business practices dating at least as far back as the early 1990s
this resulted in a heavy fine being laid against the company — €149 million, one of the largest antitrust fines applied in the history of the commission
in may 2004, nintendo announced plans to release a new brand of handheld, unrelated to the game boy, featuring two screens, one of which was touch-sensitive
the nintendo ds, released on november 21, 2004, received over three million pre-orders
in addition to the touch screen, the ds can also create three-dimensional graphics, similar to those of the nintendo 64, although its lack of hardware support for texture filtering results in more pixelated graphics than on the nintendo 64
president satoru iwata reassigned all of nintendo’s software designers under new managers and different division; most of the resources were allocated to shigeru miyamoto and takashi tezuka and the nintendo ead division
on may 14, 2005, nintendo opened its first retail store accessible to the general public, nintendo world store, at the rockefeller center in new york city
it consists of two stories, and contains many kiosks of gamecube, game boy advance, and nintendo ds games
there are also display cases filled with things from nintendo’s past, including hanafuda, nintendo’s first product
they celebrated the opening with a block party at rockefeller plaza
at e3 in may 2005, nintendo displayed the first prototype for their “next-generation” system, codenamed the nintendo revolution (now known as the wii), its controller revealed at the tokyo game show later that year
on january 26, 2006, nintendo announced a new version of their nintendo ds handheld, the nintendo ds lite, designed to be smaller and lighter, with a brighter screen
it was launched in japan on march 2, 2006, and three months later in north america and europe on june 11 and june 23, 2006, respectively
on may 25, 2006, reggie fils-aimé was promoted to president and coo of nintendo of america, inc
the former president, tatsumi kimishima, was promoted to chairman of the board and ceo
on july 7, 2006, nintendo officially established a south korean subsidiary, nintendo korea, in the country’s capital, seoul, which replaced daewon media as the official distributor of nintendo products in south korea
in early august 2006, it was revealed that nintendo, along with microsoft, was made the target of a patent-infringement lawsuit
leveled by the anascape ltd
, the suit claimed that nintendo’s use of analog technology in their game controllers constitutes a violation of their patents
the lawsuit sought to recover damages from both corporations and possibly force them to stop selling controllers with the violating technology
[35] microsoft settled with anasacape, while nintendo went to trial, initially losing and being ordered to pay

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